A novel artificial intelligence (AI) tool has revealed how disease-linked proteins misfold into harmful structures, a key advance in understanding neurodegenerative disorders such as Alzheimer’s and Parkinson’s.
The study, led by Mingchen Chen of the Changping Laboratory and Rice University’s Peter Wolynes, introduces RibbonFold, a new computational method capable of predicting the structures of amyloids — long, twisted fibers that accumulate in the brains of patients suffering from neurological decline. The study was published in the Proceedings of the National Academy of Science April 15.

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